Cryptic crossword clue
Passes away, beset by the main source of serious ailments 8

The most common and most likely answer to this crossword clue is the 8 letter word DISEASES

D
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Buddy explains!

The straight part
We know that "ailments" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ailments = diseases.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISEASES mean?

DISEASES noun
  1. An abnormal condition of a human, animal or plant that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired.
  2. (by extension) Any abnormal or harmful condition, as of society, people's attitudes, way of living etc.
  3. Lack of ease; uneasiness; trouble; vexation; disquiet.
DISEASES verb
  1. To cause unease; to annoy, irritate.
  2. To infect with a disease.

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