Cryptic crossword clue
Paul and Screw, perhaps, annoy mad woman 7

The most common and most likely answer to this crossword clue is the 7 letter word ANONYMS

I've seen this crossword clue in The Guardian
A
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Buddy explains!

The straight part
We know that "Paul and Screw, perhaps" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case paul and screw, perhaps = anonyms.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANONYMS mean?

ANONYMS noun
  1. An anonymous person.
  2. An assumed or false name; a pseudonym.
  3. A mere name; a name resting upon no diagnosis or other recognized basis.

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