Cryptic crossword clue
Peculiar interest, this, strangely requiring iron initially 6

The most common and most likely answer to this crossword clue is the 6 letter word FETISH

I've seen this crossword clue in Financial Times
F
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T
I
S
H


Buddy explains!

The straight part
We know that "Peculiar interest" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case peculiar interest = fetish.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FETISH mean?

FETISH noun
  1. Something which is believed to possess, contain, or cause spiritual or magical powers; an amulet or a talisman.
  2. Sexual attraction to or arousal at something sexual or nonsexual, such as an object or a part of the body.
  3. An irrational, or abnormal fixation or preoccupation; an obsession.

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