Cryptic crossword clue
People privy to information may have guts to cross Republican 8

The most common and most likely answer to this crossword clue is the 8 letter word INSIDERS

I've seen this crossword clue in The Daily Telegraph
I
N
S
I
D
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R
S


Buddy explains!

The straight part
We know that "People privy to information" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case people privy to information = insiders.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INSIDERS mean?

INSIDERS noun
  1. A person who has special knowledge about the inner workings of a group, organization, or institution.
  2. A person who is within an enclosed space.

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