Cryptic crossword clue
Perhaps 2s from North America with two shillings 6

The most common and most likely answer to this crossword clue is the 6 letter word NABOBS

I've seen this crossword clue in Financial Times
N
A
B
O
B
S

Buddy explains!

The straight part
We know that "Perhaps 2s" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case perhaps 2s = nabobs.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NABOBS mean?

NABOBS noun
  1. An Indian ruler within the Mogul empire.
  2. (by extension) Someone of great wealth or importance.
  3. (by extension) A person with a grandiose style or manner.

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