Cryptic crossword clue
Perhaps ironic and self-referential leader crossing Old Street, on about communist uprising 10

The most common and most likely answer to this crossword clue is the 10 letter word POSTMODERN

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "Perhaps ironic and self-referential" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case perhaps ironic and self-referential = postmodern.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POSTMODERN mean?

POSTMODERN noun
  1. A postmodernist.
POSTMODERN adjective
  1. Of, relating to, or having the characteristics of postmodernism, especially as represented in art, architecture, literature, science, or philosophy that reacts against an earlier modernism.

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