Cryptic crossword clue
Perhaps makes inappropriately large tissue for covers 8

The most common and most likely answer to this crossword clue is the 8 letter word OVERLIES

O
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Buddy explains!

The straight part
We know that "covers" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case covers = overlies.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OVERLIES mean?

OVERLIES verb
  1. To lie over or upon
  2. To suffocate by lying upon

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