Cryptic crossword clue
Perky neighbour in a street in south coast town 6,2,1,6

The most common and most likely answer to this crossword clue is the 6 plus 2 plus 1 plus 6 letter word BRIGHT AS A BUTTON

I've seen this crossword clue in The Times
B
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Buddy explains!

The straight part
We know that "Perky" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case perky = bright as a button.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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