Cryptic crossword clue
Pernicious agents altered Nixon's route 11

The most common and most likely answer to this crossword clue is the 11 letter word NEUROTOXINS

I've seen this crossword clue in The Times
N
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Buddy explains!

The straight part
We know that "Pernicious agents" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pernicious agents = neurotoxins.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NEUROTOXINS mean?

NEUROTOXINS noun
  1. A toxin that specifically acts upon neurons, their synapses, or the nervous system in its entirety.

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