The most common and most likely answer to this crossword clue is the 4 plus 6 letter word HALF BREEDS
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Buddy explains!
The straight part
We know that "Persons of mixed racial descent" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case persons of mixed racial descent = half breeds.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HALF BREEDS mean?
HALF BREEDS noun- A person of mixed racial parentage or ancestry, especially one of mixed White and American Indian parentage (metis, métis, Metis, Métis).