The most common and most likely answer to this crossword clue is the 10 letter word ACROMEGALY
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The straight part
We know that "Physical problem" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case physical problem = acromegaly.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ACROMEGALY mean?
ACROMEGALY noun- A chronic disease marked by enlargement of the bones of the extremities, face, and jaw that is caused by over-activity of the pituitary gland.