Cryptic crossword clue
Physical problem you finally found in nasty cage with pain as before 8

The most common and most likely answer to this crossword clue is the 4 letter word AGUE

A
G
U
E


Buddy explains!

The straight part
We know that "Physical problem" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case physical problem = ague.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AGUE mean?

AGUE noun
  1. An acute fever.
  2. An intermittent fever, attended by alternate cold and hot fits.
  3. The cold fit or rigor of the intermittent fever
  4. A chill, or state of shaking, as with cold.
  5. Malaria.
AGUE verb
  1. To strike with an ague, or with a cold fit.

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