The most common and most likely answer to this crossword clue is the 6 letter word CHOICE
I've seen this crossword clue in The Times
C
H
O
I
C
E
More clues leading to the result CHOICE
- Pick clubs and hearts over diamonds
- Vulgar option
- Pick house in Channel Islands, by church
- Exclusive food, but not with cold dessert
- Select frozen dessert that’s not cold in the middle
- Plum variety
- Select smart response, finally putting nothing in
- Choc-ice centre goes best
- Brill, catfish gutted with gusto, finally chilled
- Church over frozen water is exquisite
Buddy explains!

The straight part
We know that "Pick" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pick = choice.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CHOICE mean?
CHOICE noun- An option; a decision; an opportunity to choose or select something.
- The power to choose.
- One selection or preference; that which is chosen or decided; the outcome of a decision.
- Anything that can be chosen.
- (usually with the) The best or most preferable part.
- Care and judgement in selecting; discrimination, selectiveness.
- A sufficient number to choose among.
- Especially good or preferred.
- Careful in choosing; discriminating.