The most common and most likely answer to this crossword clue is the 11 letter word DISTINGUISH
I've seen this crossword clue in The Times
D
I
S
T
I
N
G
U
I
S
H
Buddy explains!
The straight part
We know that "Pick out" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case pick out = distinguish.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DISTINGUISH mean?
DISTINGUISH verb- To recognize someone or something as different from others based on its characteristics.
- To see someone or something clearly or distinctly.
- To make oneself noticeably different or better from others through accomplishments.
- To make to differ.