Cryptic crossword clue
Pioneering animal 6,3

The most common and most likely answer to this crossword clue is the 6 plus 3 letter word GUINEA PIG

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does GUINEA PIG mean?

GUINEA PIG noun
  1. A tailless rodent of the family Caviidae and the genus Cavia, with short ears and larger than a hamster; the species Cavia porcellus is often kept as a pet.
  2. A rodent of any of several species within the family Caviidae.
  3. A living experimental subject.
  4. A professional company director, without time or real qualifications for the duties.
  5. A midshipman in the East India service; (by extension) a low-skilled or non-proficient seaman.

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