The most common and most likely answer to this crossword clue is the 4 letter word PISS
I've seen this crossword clue in Independent
P
I
S
S
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PISS mean?
PISS noun- (usually uncountable) Urine.
- An instance of pissing.
- Alcoholic beverage, especially of inferior quality.
- An intensifier.
- To urinate.
- To discharge as or with the urine.