Cryptic crossword clue
Poison opening of package to New England state 8

The most common and most likely answer to this crossword clue is the 8 letter word PTOMAINE

P
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Buddy explains!

The straight part
We know that "Poison" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case poison = ptomaine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PTOMAINE mean?

PTOMAINE noun
  1. Any of various amines formed by putrefactive bacteria.
  2. Food poisoning.

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