The most common and most likely answer to this crossword clue is the 8 letter word METHANOL
I've seen this crossword clue in The Times
M
E
T
H
A
N
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L
More clues leading to the result METHANOL
- Poisonous liquid in alcohol taken by him at the end
- Ale month shifted alcohol
- Hot meal enlivened with a drop of neat alcohol
- Dangerous product of distilling walnut kernels at home
- Satisfied hotel with new loan for alcohol
- Drunken male not minimally healthy? Not if he drinks this!
- On the lam, sick from wood alcohol
- Hotel man mixed something dangerous for drinker!
- Sozzled, Thelma’s drinking no spirit
Buddy explains!
The straight part
We know that "Poisonous liquid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case poisonous liquid = methanol.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does METHANOL mean?
METHANOL noun- The simplest aliphatic alcohol, CH3OH; a colourless, toxic, inflammable liquid, used as a solvent, antifreeze, in the chemical industry, and in the preparation of methylated spirit.