The most common and most likely answer to this crossword clue is the 4 plus 6 plus 4 letter word MESS AROUND WITH
I've seen this crossword clue in The Guardian
M
E
S
S
A
R
O
U
N
D
W
I
T
H
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.