The most common and most likely answer to this crossword clue is the 5 letter word SINUS
I've seen this crossword clue in The Times
S
I
N
U
S
More clues leading to the result SINUS
- Iranians at last in American airspace
- Passage south across the Atlantic
- Wrong American gets a hole in the head
- Passage in tabloid is rejected
- Cavity made with spades in United States
- A hole, something wrong with America
- Hollow space? Not out visiting South America
- Pole in American airspace
- Partly fills in useless hole in the head
- Passage from paper is read back
Buddy explains!

The straight part
We know that "airspace" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case airspace = sinus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SINUS mean?
SINUS noun- A pouch or cavity in any organ or tissue, especially the paranasal sinus.
- A channel for transmitting venous blood.
- A notch or depression between two lobes or teeth in the margin of an organ.
- An abnormal cavity or passage such as a fistula, caused by the destruction of tissue.
- A bay of the sea; a recess in the shore.