The most common and most likely answer to this crossword clue is the 12 letter word HOLIDAYMAKER
I've seen this crossword clue in The Guardian
H
O
L
I
D
A
Y
M
A
K
E
R
More clues leading to the result HOLIDAYMAKER
Buddy explains!
The straight part
We know that "one’s taking time off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one’s taking time off = holidaymaker.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HOLIDAYMAKER mean?
HOLIDAYMAKER noun- Someone who is on holiday