Cryptic crossword clue
Poor harmony is leading issue in disco music 10

The most common and most likely answer to this crossword clue is the 10 letter word DISSONANCE

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Poor harmony" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case poor harmony = dissonance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISSONANCE mean?

DISSONANCE noun
  1. A harsh, discordant combination of sounds.
  2. Conflicting notes that are not overtones of the note or chord sounding.
  3. A state of disagreement or conflict.

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