Cryptic crossword clue
Posh Downton daughter mixes with a bit of rough! 4-3-3

The most common and most likely answer to this crossword clue is the 4 plus 3 plus 3 letter word DOWN AND OUT

D
O
W
N
A
N
D
O
U
T

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DOWN AND OUT mean?

DOWN AND OUT adjective
  1. In a condition of poverty or debility, especially as a result of experiencing a financial or personal setback.
DOWN AND OUT noun
  1. A down-and-outer.

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