The most common and most likely answer to this crossword clue is the 6 letter word ARTERY
I've seen this crossword clue in The Times
A
R
T
E
R
Y
More clues leading to the result ARTERY
- Possibly painting European railway route
- Queen aboard pretentious vessel
- Main road with some reversing tyre tracks
- Personal vessel among smarter yachts
- Queen carried in pretentiously refined vessel
- Some tyre tracks traced back in main road
- Queen contributed to cultural channel
- The way to one’s heart? Quite the opposite!
- Cockney’s hound biting overturned alien vessel
- Something that could be clogged in a foreign network before turn of year
Buddy explains!
The straight part
We know that "route" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case route = artery.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ARTERY mean?
ARTERY noun- An efferent blood vessel from the heart, conveying blood away from the heart regardless of oxygenation status; see pulmonary artery.
- A major transit corridor.