Cryptic crossword clue
Post office list their regulars as ultimate 12-acrosses 11

The most common and most likely answer to this crossword clue is the 11 letter word POINDEXTERS

P
O
I
N
D
E
X
T
E
R
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POINDEXTERS mean?

POINDEXTERS noun
  1. A bookish or socially unskilled person.

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