Cryptic crossword clue
Powder starts to act like codeine in belly 6

The most common and most likely answer to this crossword clue is the 6 letter word TALCUM

I've seen this crossword clue in Financial Times
T
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Buddy explains!

The straight part
We know that "Powder" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case powder = talcum.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TALCUM mean?

TALCUM noun
  1. Powdered and perfumed talc for toilet use.
TALCUM verb
  1. To perfume with talcum powder.

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