Cryptic crossword clue
Powerful Americans exemplified in Harrison Ford’s parts 10

The most common and most likely answer to this crossword clue is the 10 letter word PRESIDENTS

I've seen this crossword clue in The Sunday Telegraph
P
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Buddy explains!

The straight part
We know that "Powerful Americans" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case powerful americans = presidents.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PRESIDENTS mean?

PRESIDENTS noun
  1. An act in the past which may be used as an example to help decide the outcome of similar instances in the future.
  2. A decided case which is cited or used as an example to justify a judgment in a subsequent case.
  3. An established habit or custom.
  4. (with definite article) The aforementioned (thing).
  5. The previous version.
  6. A rough draught of a writing which precedes a finished copy.
PRESIDENTS noun
  1. The head of state of a republic.
  2. In presidential republics, the head of government and head of state.
  3. Primary leader of a corporation. Not to be confused with CEO, which is a related but separate position that is sometimes held by a different person.
  4. A person presiding over a meeting, chair, presiding officer, presider.

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