Cryptic crossword clue
Praise case for odourless Botox to cleanse the system 8

The most common and most likely answer to this crossword clue is the 8 letter word DETOXIFY

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Buddy explains!

The straight part
We know that "to cleanse the system" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to cleanse the system = detoxify.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DETOXIFY mean?

DETOXIFY verb
  1. To remove foreign and harmful substances from something.

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