The most common and most likely answer to this crossword clue is the 14 letter word PITCH-AND-TOSS
I've seen this crossword clue in The Guardian
P
I
T
C
H
-
A
N
D
-
T
O
S
S
Buddy explains!
The straight part
We know that "the game’s a gamble" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the game’s a gamble = pitch-and-toss.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.