Cryptic crossword clue
Predisposed to subtle spice blend 11

The most common and most likely answer to this crossword clue is the 11 letter word SUSCEPTIBLE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Predisposed to" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case predisposed to = susceptible.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SUSCEPTIBLE mean?

SUSCEPTIBLE noun
  1. A person who is vulnerable to being infected by a certain disease
SUSCEPTIBLE adjective
  1. Likely to be affected by something
  2. Easily influenced or tricked; credulous
  3. Especially sensitive, especially to a stimulus
  4. That, when subjected to a specific operation, will yield a specific result
  5. Vulnerable; (temporarily) defenseless

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