Cryptic crossword clue
Prefer I were in retirement home to make fresh connections 6

The most common and most likely answer to this crossword clue is the 6 letter word REWIRE

R
E
W
I
R
E

Buddy explains!

The straight part
We know that "I" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i = rewire.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does REWIRE mean?

REWIRE verb
  1. To replace or reconnect the wires of a device or installation.
  2. To change the functionality of something by altering the parameters or logic.

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