Cryptic crossword clue
Presence of virus; confine it somehow 9

The most common and most likely answer to this crossword clue is the 9 letter word INFECTION

I've seen this crossword clue in The Daily Telegraph
I
N
F
E
C
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Buddy explains!

The straight part
We know that "Presence of virus" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case presence of virus = infection.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFECTION mean?

INFECTION noun
  1. The act or process of infecting.
  2. An uncontrolled growth of harmful microorganisms in a host.

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