Cryptic crossword clue
Presidential staff’s serious loss of immunity reported 5

The most common and most likely answer to this crossword clue is the 5 letter word AIDES

A
I
D
E
S


Buddy explains!

The straight part
We know that "presidential staff" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case presidential staff = aides.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AIDES mean?

AIDES noun
  1. An assistant.
  2. An officer who acts as assistant to a more senior one; an aide-de-camp.

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