Cryptic crossword clue
Pretentious in “Mister Ed,” and made to suffer 8

The most common and most likely answer to this crossword clue is the 8 letter word MARTYRED

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Buddy explains!

The straight part
We know that "made to suffer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case made to suffer = martyred.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MARTYRED mean?

MARTYRED verb
  1. To make someone into a martyr by putting him or her to death for adhering to, or acting in accordance with, some belief, especially religious; to sacrifice on account of faith or profession.
  2. To persecute.
  3. To torment; to torture.

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