Cryptic crossword clue
Prevent most of the skin blemish 6

The most common and most likely answer to this crossword clue is the 6 letter word THWART

I've seen this crossword clue in The Times
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The straight part
We know that "Prevent" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case prevent = thwart.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THWART mean?

THWART noun
  1. A seat across a boat on which a rower may sit.
  2. A brace, perpendicular to the keel, that helps maintain the beam of a marine vessel against external water pressure and that may serve to support the rail.
  3. An act of thwarting; something which thwarts; a hindrance, an obstacle.
THWART verb
  1. To cause to fail; to frustrate, to prevent.
  2. To place (something) across (another thing); to position crosswise.
  3. To hinder or obstruct by placing (something) in the way of; to block, to impede, to oppose.
  4. To move (something) across or counter to; to cross.
THWART adjective
  1. Placed or situated across something else; cross, oblique, transverse.
  2. Of people: having a tendency to oppose; obstinate, perverse, stubborn.
  3. Of situations or things: adverse, unfavourable, unlucky.
THWART adverb
  1. Across the direction of travel or length of; athwart, crosswise, obliquely, transversely.
THWART preposition
  1. Across, athwart.

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