Cryptic crossword clue
Priests desperately keep on trying 7

The most common and most likely answer to this crossword clue is the 7 letter word PERSIST

P
E
R
S
I
S
T


Buddy explains!

The straight part
We know that "keep on trying" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case keep on trying = persist.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PERSIST mean?

PERSIST verb
  1. To go on stubbornly or resolutely.
  2. To repeat an utterance.
  3. To continue to exist.
  4. To continue to be; to remain.
  5. To cause to persist; make permanent.

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