The most common and most likely answer to this crossword clue is the 6 letter word UPTOWN
I've seen this crossword clue in The Times
U
P
T
O
W
N
More clues leading to the result UPTOWN
- Excited and close to time to utterly dominate dormitories
- Primarily urban precinct, territory of wealthy natives?
- Punt unsteadily, drinking old whiskey in residential area
- Part of Manhattan, as far as two quarters will get you
- Complex put on private residential area
- Having an erection? Nowt wrong, it being a residential area
- Residential quarters stateside, incumbent upon two quarters
- Unfairly put upon to confess where an American lives
- Residential area as far as the outskirts of Wigan
- Billy Joel’s type of girl — high-class platinum individual
Buddy explains!

The straight part
We know that "Primarily urban precinct, territory of wealthy natives?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case primarily urban precinct, territory of wealthy natives? = uptown.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does UPTOWN mean?
UPTOWN noun- The residential part of a city, away from the commercial center
- In the upper part of a town.
- (by extension) Of or relating to an affluent area or population.
- To or in the upper part of a town.