Cryptic crossword clue
Primate conducting Mass departs energised 5

The most common and most likely answer to this crossword clue is the 5 letter word AMPED

A
M
P
E
D

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The straight part
We know that "energised" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case energised = amped.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does AMPED mean?

AMPED verb
  1. (usually with up) To amplify.
  2. (usually with up) To excite.
  3. (usually with up) To intensify or increase.

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