The most common and most likely answer to this crossword clue is the 6 letter word TITIAN
I've seen this crossword clue in Financial Times
T
I
T
I
A
N
More clues leading to the result TITIAN
- He painted first of infants captured by giant
- One of great strength protecting island painter
- Giant welcoming island painter
- Artist, a towering figure around Italy
- Note repeatedly a name for artist
- Old master seeing specialist after op, by the sound of it?
- Reddish-brown monkey with a tail of maroon
- It doubles up with an old master
- Painter‘s current giant frames
- Primordial god inspires current Italian painter
Buddy explains!

The straight part
We know that "Italian painter" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case italian painter = titian.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TITIAN mean?
TITIAN noun- A bright auburn colour, tinted with gold.
- Of a bright auburn colour, tinted with gold, especially in reference to hair.