The most common and most likely answer to this crossword clue is the 6 letter word PUEBLO
P
U
E
B
L
O
More clues leading to the result PUEBLO
Buddy explains!
The straight part
We know that "American native" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case american native = pueblo.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PUEBLO mean?
PUEBLO noun- A community in Spain or Spanish America, especially one of Pueblo Indians living in a stone or adobe multi-storey building.