Cryptic crossword clue
Principal holding gym class in the Plough, say? 6

The most common and most likely answer to this crossword clue is the 6 letter word HEPTAD

I've seen this crossword clue in Financial Times
H
E
P
T
A
D


Buddy explains!

The straight part
We know that "the Plough, say" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the plough, say = heptad.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEPTAD mean?

HEPTAD noun
  1. A group of seven things.
  2. A sequence of seven bases.

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