Cryptic crossword clue
Principal sets up computers 10

The most common and most likely answer to this crossword clue is the 10 letter word MAINFRAMES

I've seen this crossword clue in The Daily Telegraph
M
A
I
N
F
R
A
M
E
S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MAINFRAMES mean?

MAINFRAMES noun
  1. A large, powerful computer able to manage very many simultaneous tasks and communicate with very many connected terminals; used by large, complex organizations (such as banks and supermarkets) where continuously sustained operation is vital

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