The most common and most likely answer to this crossword clue is the 8 letter word INSOMNIA
I've seen this crossword clue in The Times
I
N
S
O
M
N
I
A
More clues leading to the result INSOMNIA
- Problem one's presumably unable to sleep on
- It prevents you going off
- Popular mason disturbed about current sleep disorder
- No simian suffers inability to doze
- You won’t be caught napping with this
- Sleepers, awake! is no cure for this!
- What can put off a productive retirement?
- It’s always Sleepless in Seattle’s opening I moan about
- This has one in mansion tossing and turning
- A minion’s faltering complaint
Buddy explains!
The straight part
We know that "Problem one's presumably unable to sleep on" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case problem one's presumably unable to sleep on = insomnia.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INSOMNIA mean?
INSOMNIA noun- A sleeping disorder that is known for its symptoms of unrest and the inability to sleep.