Cryptic crossword clue
Process corn to start with, then harvest ripe East Sussex hops

The most common and most likely answer to this crossword clue is the 6 letter word THRESH

I've seen this crossword clue in The Guardian
T
H
R
E
S
H


Buddy explains!

The straight part
We know that "Process corn" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case process corn = thresh.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does THRESH mean?

THRESH verb
  1. To separate the grain from the straw or husks (chaff) by mechanical beating, with a flail or machinery.
  2. To beat soundly, usually with some tool such as a stick or whip; to drub.

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