Cryptic crossword clue
Program in Excel — to begin with it can ease the pain 7

The most common and most likely answer to this crossword clue is the 7 letter word CODEINE

I've seen this crossword clue in The Guardian
C
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Buddy explains!

The straight part
We know that "it can ease the pain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case it can ease the pain = codeine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CODEINE mean?

CODEINE noun
  1. An addictive alkaloid narcotic derived from opium and used as a hypnotic, analgesic and cough suppressant; often mixed with aspirin etc.

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