The most common and most likely answer to this crossword clue is the 6 letter word TRULLS
T
R
U
L
L
S
Buddy explains!
The straight part
We know that "Prostitutes" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case prostitutes = trulls.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TRULLS mean?
TRULLS noun- A female prostitute or harlot.
- A set of three special trump cards used in some Tarock games, having a higher value than the other trumps.