Cryptic crossword clue
Protection from Philistine’s beginning to massacre harmony 8

The most common and most likely answer to this crossword clue is the 8 letter word IMMUNITY

I've seen this crossword clue in The Guardian
I
M
M
U
N
I
T
Y

Buddy explains!

The straight part
We know that "Protection" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case protection = immunity.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMMUNITY mean?

IMMUNITY noun
  1. The state of being insusceptible to something; notably:
  2. A resistance to a specific thing.

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