Cryptic crossword clue
Protest ignited by institute concerned with ruin 10

The most common and most likely answer to this crossword clue is the 10 letter word DEMOLITION

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "ruin" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ruin = demolition.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEMOLITION mean?

DEMOLITION noun
  1. The process of demolishing or destroying buildings or other structures.

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