The most common and most likely answer to this crossword clue is the 6 letter word MEDIUM
I've seen this crossword clue in The Guardian
M
E
D
I
U
M
More clues leading to the result MEDIUM
- This writer slow to introduce uniform method
- Today's compiler slow to introduce universal method
- One might be full of spirit, but mean
- Psychic found between Little and Large
- Channel One due to collapse in two minutes
- Daedalus’s Dictum: forget the beginnings of crosswords. That means …
- English copper stops silent vehicle
- She may raise people’s spirits
- A ‘person of spirit’ not going to extremes
- Film, for instance that’s neither rare nor well done
Buddy explains!

The straight part
We know that "Psychic/between Little and Large" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case psychic/between little and large = medium.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MEDIUM mean?
MEDIUM noun- (plural media or mediums) The chemistry of the surrounding environment, e.g. solid, liquid, gas, vacuum, or a specific substance such as a solvent.
- (plural media or mediums) The materials or empty space through which signals, waves or forces pass.
- (plural media or mediums) A format for communicating or presenting information.
- (plural media or mediums) The materials used to finish a workpiece using a mass finishing or abrasive blasting process.
- (plural media or mediums) A nutrient solution for the growth of cells in vitro.
- (plural media or mediums) The means, channel, or agency by which an aim is achieved.
- (plural mediums or media) A liquid base which carries pigment in paint.
- (plural mediums or media) A tool used for painting or drawing.
- (plural mediums) Someone who supposedly conveys information from the spirit world.
- (plural mediums) Anything having a measurement intermediate between extremes, such as a garment or container.
- (plural mediums) A person whom garments or apparel of intermediate size fit.
- (plural mediums) A half-pint serving of Guinness (or other stout in some regions).
- A middle place or degree.
- An average; sometimes the mathematical mean.
- The mean or middle term of a syllogism, that by which the extremes are brought into connection.
- Arithmetically average.
- Of intermediate size, degree, amount etc.
- Of meat, cooked to a point greater than rare but less than well done; typically, so the meat is still red in the centre.
- To a medium extent