Cryptic crossword clue
Publisher’s head honcho working in Middle East region being wary of web developer? 13

The most common and most likely answer to this crossword clue is the 13 letter word ARACHNOPHOBIA

I've seen this crossword clue in Independent
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The straight part
We know that "being wary of web developer?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case being wary of web developer? = arachnophobia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ARACHNOPHOBIA mean?

ARACHNOPHOBIA noun
  1. An abnormal or irrational fear of arachnids (especially spiders).

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